The nine best magnesium preparations.
*Review of the best according to the editorial board of expertology.. About the selection aspects. This material is personal, not an advertisement and does not constitute advice to purchase. You should consult with a specialist before buying.
On the market, or in the non-prescription access, there are a huge number of different multivitamins and mineral supplements that contain magnesium in the form of various compounds. Why do we need magnesium?? What periods of life require an increased expenditure of it?? What products sold in pharmacies are the best in balance, digestibility and cost? These questions are answered by the actual rating of over-the-counter magnesium products. All prices are given for the period of spring of two thousand and nineteen years for the pharmacies of all affiliations in the Russian Federation. But to begin with the biological role of this element, to know the causes of its deficiency.
If you “scrape the piles” of our body, then pure magnesium in each of us will not be more than twenty five to twenty six grams. But this amount is more than enough to power many millions of enzyme molecules, more than three hundred different kinds of enzymes. Magnesium in ionized and bound forms plays an important role in maintaining water-salt and electrolyte balance, takes part in the transport of molecules across membranes. Ions of the metal are needed to maintain physiological muscle tone, including vascular smooth muscle and internal organs, which are innervated by the autonomic nervous system. Magnesium is able to induce inhibition in the central nervous system, is considered an anti-stress factor.
About one in three people suffers from magnesium deficiency because of magnesium deficiency in food. A more frequent cause of this deficiency is the use of agricultural fertilizers and the leaching of magnesium from the ground. This results in a deficiency of the element in crops, cereals and vegetables. The second reason is long thermal processing that destroys the organic compounds of magnesium that are more assimilable by the body.
About the causes of deficiency and daily requirements.
For healthy adults, a mild magnesium deficiency is not any critical condition, but for patients with epilepsy and convulsive syndromes, severe forms of atherosclerosis and diabetes, arterial hypertension and osteoporosis, the lack of this metal can cause serious complications. During breastfeeding and pregnancy, an elevated magnesium intake is required, but this is normal. Similarly, a lot of magnesium is consumed during childhood and adolescence, due to the body’s rich growth and maturation, and the activation of enzyme systems.
A high consumption of magnesium occurs in athletes and persons engaged in arduous muscular labor. Magnesium is excreted with later, and therefore people, who often visit doubles and saunas, need to compensate the arising lack with more intensity. To the lack of this element also lead to a variety of sensual loads, insomnia, countless travels, leading to the paradox of jet lag, when a person is away from his own time zone for a long enough time.
Acquired magnesium deficiency also occurs in the elderly. In this case, the low concentration of this element in the blood leads to the highest levels of calcium, and this increases blood clotting, and leads to excessive thrombosis.
After all, diuretics, alcoholic beverages, and frequent coffee consumption can also lead to repeated magnesium washout from the body. With its deficiency in most cases, insomnia, restlessness, and lethargy appear in mild cases. Severe hypomagnesemia leads to an increased tendency to convulsive seizures.
What is the daily requirement for this metal?? On average, four hundred to eight hundred mg per day. If there is a deficiency, which can easily be determined by laboratory examination, up to thirty mg of magnesium per kilogram of body weight should be added daily. It is better to have it in the body in combination with pyridoxine or pyridoxalphosphate. It’s vitamin B6, and it improves resistance to stress. Because low stress tolerance promotes magnesium deficiency, this combined use of magnesium and vitamin B6 is considered helpful.
Rating of the best magnesium preparations.
Nomination place product name cost Best Magnesium Citrate one Magnesium Express five hundred thirty five ₽ two Magnelis B6 Forte four hundred and sixty eight ₽ three Magnesium Helate Evalar nine hundred and thirty three ₽ Best Magnesium Asparaginate one Panangin, Panangin Forte three hundred forty three ₽ two Asparkam forty three ₽ best Magnesium Lactate one Complivit Magnesium two hundred thirty two ₽ two Magne B6 four hundred seventy six ₽ three Magnelis B6 three hundred two ₽ four Magnesium Orotate: Magnerot (Magnemax) six hundred thirty three ₽
Currently, there are a huge number of modern magnesium-containing drugs that can reduce the nasty symptoms of hypomagnesemia, and replenish its physiological supplies. But not all drugs are equally well absorbed and tolerated. In pharmacies there are both compounds of magnesium ions with organic acids and with inorganic.
Examples of organic magnesium compounds are magnesium lactate, orotate, asparaginate, malate, and citrate. These names stand for the radicals of organic acids, which act as anions – the negatively charged parts of an otherwise electrically neutral molecule. Accordingly, we are talking about compounds of magnesium ions with lactic acid (lactate), orotic acid (orotate), aminoic acid (asparaginate), malic acid (malate), and citrate. All of these compounds are popular, are part of many drugs and dietary supplements, and will be described below.
There are also inorganic compounds, which are represented as magnesium sulfate or ordinary magnesium sulfate, also in the form of magnesium oxide. The distinctive quality of these inorganic substances is their inadaptability to compensate for magnesium deficiencies. The thing is that their bioavailability, in other words absorption by the body naturally, through the organs of the gastrointestinal tract, is very low. Therefore, magnesia or magnesium sulfate is an excellent treat for constipation and can also be given intravenously in case of emergency. It cannot be used as a long-term supplement to make up for deficiencies.
The same is true of magnesium oxide. In some cases, preparations that include magnesium oxide are indicated for constipation, but are not biologically active supplements. Let us review the more active, popular, and non-hazardous preparations containing magnesium.
The best magnesium citrate.
Open the list of drugs containing magnesium citrate, or magnesium compound with citric acid. Both magnesium and citric acid are absorbed in the body because they participate in the Krebs Cycle or the tricarboxylic acid cycle. That is why citrate, which is taken in limited quantities in order to prevent the lack of this element, also activates bio-oxidation and cellular respiration. The bioavailability of all magnesium citrate preparations is quite high; they are highly effective and healthy.
Magnesium Express is a combination of magnesium citrate and vitamin B6. This combination is considered mutually beneficial, and enhances the effect of both components. Magne Express is indicated not only for the correction of mild deficiencies but also as a prophylactic, biologically active food supplement.
It is clear that the main source of magnesium in food are nuts, grains, various seeds, halva and green vegetables. So in this case, if there is a lack of these food products, or their cooking foresees a long thermal effect, there may be a lack of magnesium. Magne Express is available in sachets, in the form of sachets. Inside each sachet are special granules for swallowing.
This product should be taken in one sachet twice a day and swallowed with food. It is not necessary to wash down with water. The average duration of the course is about one month. The taste of the pellets is sweet and sour, and they remind us of the smell of tropical fruits. Produces Magne Express Austrian pharmaceutical company Hermes, and the price of one pack of twenty sachets, on average, is five hundred twenty rubles.
Pros and cons COCADO from Portuguese to English.
Despite the fact that the bioavailability of magnesium citrate is the highest, this remedy is recommended to use in the form of a food supplement, but to compensate for the developed hypomagnesemia with its help should not. There are special preparations for this purpose, such as the ampouled product Magnesium B6, which is magnesium lactate and is described below. Therefore, Magne Express should not be used during pregnancy and lactation, with a severe form of renal deficiency, as well as if the patient takes levodopa medications for the treatment of Parkinsonism. The relative disadvantage will be quite high cost: a monthly course of Magnet Express will cost the patient about one thousand rubles.
Magnelis B6 Forte.
Magnelis B6 Forte is the traditional compound of magnesium citrate and pyridoxine hydrochloride, or vitamin B6. Each tablet contains six hundred eighteen mg of magnesium citrate, which is equivalent to one hundred milligrams of an ionized form of the unstained metal. The product is available in pills, in a package of sixty pieces.
Magnelis B6 Forte is indicated to heal deficiencies of this element, both isolated and associated with other conditions, such as hypovitaminosis and diagnosed nutritional deficiencies. Clinical signs for which this product is prescribed may include irritability, stomach and intestinal cramps, elevated heart rate, paresthesias and crawling sensations in muscles, nasty pain in them, and various muscle cramps.
Magnelis B6 Forte is taken usually from three to four pills a day, depending on the severity of the magnesium deficiency, with meals. Low dose – two pills a day. Standard course of treatment is one month. Magnelis B6 Forte is produced by the Russian manufacturer Pharmstandart at the facilities of Tomsk Chemical Pharmaceutical Plant. The average price for a pack of sixty pills is five hundred fifty rubles. Depending on the dose – it can be ten days of intake or a whole monthly course if taken once a day for two pills.
Advantages and disadvantages.
The virtue of this product will be the ability to make up for magnesium deficiencies, but like all magnesium-containing products, there are contraindications. It is a serious form of acquired renal deficiency, again taking levodopa, also age under twelve years. This fact is due to a lack of research work, and so in this case, if the child is diagnosed with a magnesium deficiency, then in this case you need to take another product that can be prescribed to children. Next, such a product will be described – it is Magnesium B6 in ampoules. Also a relative disadvantage may be the highest price. If a person takes four pills a day, then a pack of sixty pills it will be enough only for two weeks, and a monthly course will cost one thousand rubles.
Magnesium Chelate Evalar.
What are chelate compounds?? They have nothing to do with the robe and negligence. A chelate complex is a special kind of compound of large molecules with metal atoms that immediately gives a stable structure and protects the metal from various chemical reactions. Chelates help to transport it to the right place, and then the chelate complex relaxes into parts, and the metal ion begins to have an active effect where it is needed. It is quite difficult to produce chelate complex. For this purpose it is necessary to have a modern chemistry creation.
Exactly such a high-tech creation is currently launched in the company Evalar. Magnesium Chelate from Evalar is an opportunity to get all-available and easily digestible form of magnesium. It is easily absorbed because it does not require additional transformation in the body. Its digestibility is actually 100%. Clients tolerated chelated form of magnesium, as well as other metals, very well, and can seep through the transplacental barrier.
Magnesium Helate from Evalar is indicated as a dietary supplement, for the prevention of stress and cardiovascular diseases, for the maintenance of health during pregnancy and lactation. Magnesium Helate is indicated for adults and children over fourteen years of age. These pills are expensive: a pack of sixty pills will cost an average of nine hundred and twenty rubles. According to the annotation, both adults and children need to take one to two pills a day with food. The course is a month. This means that the package is enough for just a month course.
Pluses and Disadvantages.
A huge advantage of chelated magnesium is its high bioavailability, not a bad tolerance and digestibility, the ability to mildly conduct the prevention of various conditions associated with a lack of magnesium. Even the relatively high cost shouldn’t be frightening, since one pack is enough for one month’s course at once.
But there are also imminent disadvantages, which are absolutely not related to the form of release, but to the intake of the element itself. This, as in the previous case, healing with levodopa products and severe forms of renal deficiency, in which it is simply contraindicated to load the body with magnesium ions, which the unhealthy kidneys will not be able to eliminate. Also, the Evalar company does not produce pharmaceuticals, and therefore the indications do not include a diagnosis of mild and moderate hypomagnesemia. Therefore, it is necessary to take this product for your own pleasure with a preventive purpose.
The best magnesium asparaginate.
Perhaps specifically asparaginate magnesium and potassium is better known to older people and clients who are being healed by a cardiologist. The fact is that in the Russian Federation, such recognizable pharmaceuticals for the prevention of magnesium and potassium deficiency as Panangin and Asparkam are most sold. In these pharmaceutical forms, the magnesium and potassium ions are combined with an asparagine or aminoyanthic acid residue. This amino acid residue is also of great importance for nitrogen metabolism, participating in the synthesis of pyrimidine bases, which then serve in nucleic acids. Potassium and magnesium asparaginate preparations are not characterized by poor bioavailability, and the most common of them are Panangin and Asparkam.
Panangin, Panangin Forte.
Above it was noted that Panangin and Asparkam love to prescribe therapists and cardiologists in the main, to older people. The fact that Panangin includes, in addition to magnesium and potassium, and specifically the lack of potassium often leads to disorders of cardiac activity and heart rate. Why can there be a lack of potassium? Yes, because the old can take drugs to heal arterial hypertension, and often among them are diuretics, which withdraw potassium from the body.
Therefore, Panangin is first shown in various arrhythmias and cardiac arrhythmias, as a preventive measure in the treatment with cardiac glycosides, because potassium deficiency may occur, and only lastly – as a preventive measure or food additive in the absence of potassium and magnesium. Unlike the above remedies, Panangin is positioned as a true remedy.
Use Panangin or Panangin Forte after meals. Panangin Forte differs from the ordinary Panangin in the number of substances: one tablet contains three hundred and sixteen mg of potassium asparaginate and two hundred and eighty mg of magnesium asparaginate, while the ordinary Panangin contains one hundred fifty and one hundred forty mg respectively. The usual course of treatment is one month, the maximum daily dose is three pills three times a day. Panangin and Panangin Forte are produced by the Hungarian company Gedeon Richter and the price of a pack of fifty pills is one hundred rubles. There are also intravenous forms of administration, which are used in hospitals.
Pros and cons.
The advantage of Panangin and Panangin Forte will be a compound of magnesium with potassium. It is at once a good publicity stunt, and the opportunity to make a better healing effect at once, since potassium and magnesium deficiencies are dictated by the same mechanisms. The product is perfectly tolerated and cheap, but contraindications should be taken into account, among which are acquired renal deficiencies, increased concentration of magnesium and potassium, and a volume form of atrioventricular block, as before. Caution should be exercised when taking Panangin and Panangin Forte during pregnancy, and especially during the first trimester, because potassium preparations can cause significant harm to the baby if they are in excess. A pack of fifty pills costs, on average, only forty eight rubles, and Asparkam is produced by the Russian company Medisorb.
Asparkam can be completely considered a “budget” analogue of Panangin. Each tablet contains equal parts of magnesium and potassium asparaginate – one hundred and seventy five milligrams each. There is no particular difference between Asparkam and Panangin, which is described above – neither in evidence, nor in contraindications, nor in the mode of intended use. But some patients note that it is somewhat more coarse. And not about the direct action, but about the sensations specifically after taking it. There may be heaviness in the stomach, a slight burning sensation in the epigastric region. It is particularly not uncommon for these symptoms to occur in patients with cholecystitis or gastritis with reduced acidity.
Similarly, the list of contraindications when taking Asparkam contains atrioventricular block, hyperkalemia, hypermagnesemia. The only significant advantage of Asparkam is its availability and low cost.
The best magnesium lactate.
The drug industry produces a substantial number of different all-encompassing magnesium compounds based on lactate, or lactic acid. These include Complivit Magnesium, Magne B6, and other products. Lactate should not be confused with lactose. Lactose is called “milk sugar” and lactate is occasionally figuratively referred to as “blood sugar” as lactic acid is nothing more than an intermediate product of the physiological breakdown of glucose, the head energy substrate.
Complivit Magnesium is named so purely for commercial purposes. Unlike all the above products, which contain either only magnesium compounds or half and half – magnesium asparaginate and potassium, Complivit Magnesium is a real vitamin and mineral complex. It contains vitamin A, vitamin E, B vitamins, ascorbic acid, calcium pantothenate, folic acid, vitamin B12, compounds of copper, zinc – and, finally, magnesium lactate. Therefore, it could easily be called anything: Complivit copper, Complivit zinc, or Complivit folic acid. There would be no difference apart from the other names.
It is necessary to use this remedy once a day, the duration of intake with a preventive purpose – one month. The annotation specifically states that this product is not a medicine. This product is manufactured by Pharmstandart company, Ufa Vitamin Plant. One pack of sixty multivitamin pills costs, on average, two hundred rubles. This, of course, is cheap.
Pros and cons.
Since Complivit Magnesium is not considered a drug, then among the contraindications can be named only personal intolerance. If the product is not registered as a pharmaceutical product, then officially you can not write anything about the contraindications to reception, because contraindications are only for pharmaceuticals. Of course, in the case of personal intolerance to the components will certainly be appropriate indication in the summary, and that is how to really distinguish dietary supplements from pharmaceuticals. The only disadvantage will be the preventive orientation. If the doctor diagnosed a lack of elements, then it makes no sense to take multivitamin complexes, which are added “just a little bit. It is necessary to treat only with products that are specifically designed to correct the deficiency, and such a drug will be discussed right now. This is Magne B6.
Magne B6 is available in two pharmaceutical forms: pills, also a solution for intravenous administration. Let us describe this product using the solution as an example. Magnesium B6 is available in ampoules, but not for intravenous or intramuscular injection, but to break them, shake in a glass of water and drink. Each ampoule contains magnesium lactate. Collectively, taking three or four ampoules once a day not only allows the body to fully meet its need for the element, but also quickly eliminates its deficiency. Magnesium B6 in the form of water is a brown solution with a faint odor of caramel.
It is indicated for use if the patient has conditions such as gastrointestinal cramps, tachycardia, muscle cramps and muscle soreness, irritability, and a nasty tingling sensation in the muscles against the background of excessive magnesium consumption. If the laboratory method will be detected by a lack of plasma magnesium, Magnesium B6 in ampoules can quickly restore the deficiency. Thus, the indication for use is clinically and laboratory confirmed magnesium deficiency. One of the more common indications for use is pregnancy, as well as alimentary deficiencies or nutritional deficiencies during pregnancy.
It should be taken with food, for adults – up to four vials a day. It is recommended for children over the age of one year at a dose of ten to thirty mg per kilogram, but the administration should be made by the paediatrician after proving hypomagnesemia. Usually an ampoule for adults is diluted in half a glass of water, and after controlling and normalizing the level of this element, the healing is stopped.
Produces Magne B6 French company Sanofi-Aventis, the average price of ten ampoules of ten ml. any is five hundred rubles.
Pros and cons.
The advantage of Magnes B6 in ampoules is the ability to rapidly correct magnesium deficiency, not bad tolerance, and the ability to prescribe it to children, which is unique in the world of magnesium supplements. The relative disadvantage will be the high price, not a completely successful administration when you need to use an ampoule, even with self-breaking tips. It is necessary to keep in mind that the product should not be used with low glomerular filtration and severe forms of renal failure, even in this case, if the patient takes levodopa or cures Parkinsonism.
The product Magnelis B6 Forte, which is magnesium citrate, has already been described above. But, as it turns out, there is also just Magnelis B6, which has nothing to do with citric acid, but is magnesium lactate. In terms of magnesium, one tablet contains forty eight mg of magnesium, plus five mg of vitamin B6 – pyridoxine hydrochloride.
The product is indicated first to treat deficiencies of this element and those symptoms that occur when serum magnesium drops below 0.5 mmol per liter. The symptoms are: spastic and nasty pains in the epigastrium and stomach area, rapid heart rate, weakness, irritability and insomnia, nasty and painful muscle tingling and cramps. The product is indicated for adults and children over six years of age and should be taken from six to eight pills a day for adults and up to six pills once a day for children whose body weight exceeds twenty kg.
All pills should be divided into two or three meals, take the product with food. But after normalization of magnesium concentration in blood plasma the treatment is stopped. The product Magnelis B6 manufactures the Russian company Pharmstandard, and the price of one package of ninety pills, designed for at least two weeks of intake, is five hundred fifteen rubles. If you want, you can find this package in pharmacies and at the cost of three hundred and eighty rubles, but it is not often. Therefore, the average monthly price of the course will be nine hundred – one thousand rubles.
Pros and cons.
This product has several small, but disgusting flaws. First, there is the product Magnelis B6 Forte, which is not a lactate, and citrate. According to established medical tradition, usually products with the prefix “Forte” refers to a product in which there is either an increased dose or some other component is added. In this case, from a legal point of view, Magnelis B6 Forte is a completely different substance, although it contains magnesium. This can lead to some dislocation, and especially in pharmacies, when front desk workers may recommend a similar product. The 2nd small disadvantage, but also nasty, is the need to take a huge number of pills once a day, and taking each of them asks you to wash down with water, and this must be done with food. This is not comfortable for many, and therefore skipping such a product is likely, since the patient’s adherence to the intake is far from flawless. It would be even better to choose such a dosage that the product is prescribed once or twice a day. Magnesium orotate: Magnesium Orotate: Magnesium Orotate is not chemically active.
Magnesium orotate: Magnerot (Magnemax)
The structure of orotic acid is slightly similar to that of a vitamin, and it is often used as an organic radical to combine with various metals such as iron, calcium, and magnesium. Any organic radical increases the bioavailability of the metal, and therefore magnesium orotate has the same right to medical use as lactate or asparaginate. One of the traditional representatives of magnesium orotate is the biologically active supplement Magnerot.
Each tablet of Magnerot contains five hundred mg of magnesium orotate. This product is indicated mainly for cardiology patients. This is exactly what the leaflet recommends. Despite the fact that it could fully position itself as a means to prevent and cure magnesium deficiency, manufacturers have decided to take a narrower niche. That is why Magnerot is indicated for clients with heart attack, ischemic heart disease, acquired cardiac deficiencies and heart rhythm disorders, muscle pain, lipid metabolism disorders and atherosclerosis.
Thus, manufacturers have gone the way of symptomatic indications. On the one hand, it’s even easier and angina patients will take Magnerot even better, and doctors will prescribe it better. Produces Magnerot German company Mayermann, or the Russian PIK – Pharma, and one pack of fifty pills will cost about six hundred fifty rubles. Used Magnerot two pills three times a day, so this package is enough for eight days of intake. This is a fairly expensive product, especially when you consider that the monthly course will need four packs, each costing six hundred fifty rubles.
Pros and cons.
Magnerot, or magnesium orotate, has no significant advantages over other products. Yes, magnesium orotate has good bioavailability, but lactate also has good bioavailability, and the chelate complexes have even higher bioavailability. The price of this product is quite high, the contraindications are exactly the same, and since the manufacturers positioned it as a product for cardiovascular disease, they put in the list of contraindications liver cirrhosis, ascites, urolithiasis with susceptibility to the formation of magnesium, phosphate, calcium and ammonium stones. Thus, clients with urolithiasis in virtually all forms of calculi should not use this product, especially during long courses. Since increasing the list of contraindications reduced the number of future customers, we had to raise the price to minimize the planned losses.
Compliance, in other words, patient adherence is not very high, because the product should be used in a dose of six pills for seven days, and later – one tablet three times a day. Perhaps if Magnerot had a price on the order of two hundred thirty to two hundred and forty rubles., It would be fully competitive, but otherwise – it’s just a regular product of magnesium with a not entirely comfortable method of ingestion at a very high cost.
This ends the review of magnesium preparations that can be found in Russian pharmacies at affordable prices. Of course, the above products, the list of supplements containing magnesium, is not exhausted. So, as a part of the chelated form may be magnesium glycinate, there are supplements in the form of malate, in other words, magnesium salts of malic acid. Magnesium taurinate, a rarity, can also be found. Magnesium from marine aquatic plants isolated from Dead Sea salts can be found in internet stores. Occasionally an aqua solution of magnesium chloride is used that can be applied to the skin and rubbed in. But all these supplements are quite expensive, and have no significant advantage over the above list of favorite magnesium preparations.